baumannii was one of the most frequent pathogens isolated from patients hospitalized in the ICU for severe COVID-19 pneumonia 4 or bacteremia 5. These results demonstrate both planktonic and biofilm antigens are important during antigen selection for vaccine design.ĭuring the COVID-19 pandemic, studies have shown ESKAPE pathogens ( Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) have severely affected the treatment of patients admitted in ICUs 1, 2, 3. baumannii was an excellent achievement with our quadrivalent immunogen. ![]() Complete bacterial clearance from all the affected tissues of the mice challenged with A. The results showed that the combined vaccine elicited high IgG antibody titers and conferred protection against lethal doses of two Carbapenem-resistant high adherent A. baumannii during growth and attachment, we combined planktonic upregulated antigens of iron receptors with biofilm upregulated antigens of pilus rods and evaluated immune responses and protective efficacies of the combined vaccine using lethal and sub-lethal murine sepsis models. ![]() baumannii infections, many attempts have been made to develop vaccines using planktonic or biofilm antigens. Acinetobacter baumannii is a multi-drug resistant pathogen with the ability to switch between planktonic and biofilm phenotypes.
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